Leptin Knockout

Gonadotropic Cell - Wikipedia, The Free Encyclopedia
Gonadotropes are endocrine cells in the anterior pituitary that produce the gonadotropins, such as the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). ... Read Article

Adiponectin And Adiponectin Receptors - Endocrine Reviews
Free fatty acid (3), adipsin (4), leptin (5), plasminogen acti-vator inhibitor-1 (6), resistin (7), and TNF- (8). liferator-activated receptor) knockout mice that remained insulin-sensitive on a HF diet (38). In an attempt to identify ... Document Viewer

Perilipin Ablation Results In A Lean Mouse With Aberrant ...
Aberrant adipocyte lipolysis, enhanced leptin production, and resistance to we have created a perilipin knockout mouse. Perilipin null (peri2/2) and wild-type (peri1/1) mice con-sume equal amounts of food, but the adipose tissue mass in the ... Retrieve Doc

REVIEW Pro-opiomelanocortin Processing In The Hypothalamus ...
As leptin (Montague et al. 1997, Strobel et al. 1998) and the leptin receptor (Clement et al. 1998). First, MC4R knockout mice demonstrate an obese phenotype, owing to severe hyperphagia (Huszar et al. 1997). This confirms a role for the receptor in ... Fetch Full Source

Insulin-like Growth Factor - Wikipedia, The Free Encyclopedia
Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways. Adipose tissue: leptin ... Read Article

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Product Data - D12451 Report Repeat Revise
Leptin-Induced Changes in Body Composition in High Fat-Fed Mice. AJPRegul Integr Comp Physiol 284:R87-R100, 2003. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet. Diabetes 51:3211-3219, 2002. ... Retrieve Here

Eating Disorders And Memory - Wikipedia, The Free Encyclopedia
Previous studies have identified the effect of the adipocyte hormone leptin, reveal that leptin treatments reverse obesity in knockout mice (ob/ob), and that diabetic (db/db) and Zucker fatty (fa/fa) rats display similar obesity phenotypes. Work on characterizing rodent obesity syndromes ... Read Article

Adipose Tissue As An Endocrine Organ - Cosmetic And Medical ...
Leptin Adiponectin TNF IL-6 Resistin RBP4 Nutrient signaling Innate immunity Cytokines Insulin sensitivity Obesity abstract al., 2002) or the knockout of the AMPK 2 subunit (Andreelli et al., 2006) results in increased hepatic glucose output and glucose ... Document Retrieval

The Metabolic Syndrome Resulting From A knockout Of The NEIL1 ...
We generated knockout (KO) mice with a frameshift deletion and insertion in the neil1 gene. Results Construction of neil1 KO Mice. circulating leptin levels were assessed as an independent measure of adipose tissue burden, because plasma concentrations of leptin are generally ... Access Doc

PowerPoint Presentation
PLA2 knockout causes hypertrophy FAK Micro RNAs are induced during myogenesis and regulate myostatin expression IGF-1, insulin, IGF-2 receptor leptin, adiponectin T308 S473 Fast-to-slow phenotype transformation PGC-1a phosphorylation, mitochondrial biogenesis Links to Smad signalling LKB1 S9 S21 ... Retrieve Full Source

Diabetes Impairs Hematopoietic Stem Cell Mobilization By ...
Leptin receptor knockout (db/db) mice were purchased from the Jackson Lab-oratory. All mice were housed according to Institutional Animal Care and Use Committee guidelines and used at 12 to 18 weeks of age. Experimental HSC mobilization and blood collection ... Read Document

Original Article The Narcoleptic Borderland: A Multimodal ...
Leptin, and increased ‘time asleep’ on actigraphy appeared to be over-represented in both hypersomnia associated with in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999;98:437–451. [7] Peyron C, Faraco J, Rogers W, et al. ... Get Doc

CNS Regulation Of Glucose Homeostasis - Physiology
Leptin, and most recently identified, glucagon-like pep-tide (GLP)-1, and 2) nutrients (63, 85, 93), namely fatty selective brain IRS-2 knockout mice (112). The mechanism downstream of central insulin-sig-naling to regulate peripheral glucose homeostasis ... Fetch Document

Debra D. Canabal, Joseph G. Potian, Ricardo G. Duran, Joseph ...
Lular glucose, insulin, and leptin regulate glucose-excited (GE) and glucose-inhibited (GI) neurons in the ventromedial hypothalamus (VMH). NOS knockout mice (Abstract). Soc Neurosci Abstr Viewer/Itinerary Planner 615.14: 2003. 32. ... Fetch Full Source

65th Annual Meeting Of The American Society For Reproductive ...
Trophoblastic-specific Leptin Receptor Knockout for Study of Leptin Function in Placenta." Society for Reproductive Endocrinology and Infertility, National Research Service Institutional Training Award (T32) The Society for Reproductive Endocrinology and ... Retrieve Full Source

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REVIEW AMPK As A Mediator Of Hormonal Signalling
AMPKa2-knockout (KO) and LKB1-KO mice were shown to have glucose intolerance and fasting-induced hyperglycaemia, possibly caused by increased Figure 1 AMPK regulation: AMPK’s upstream kinases Leptin increases AMPK activity in the skeletal muscle ... Fetch Here

Genetically Modified Mouse Models For The Study Of ...
Leptin gene (leptin-deficient). These mice are hyperpha-gic, inactive, extremely obese and are severely diabetic, knockout mice the binding and actions of adiponectin are abolished, resulting in increased tissue triglyceride content, ... Fetch Full Source

THE BEHAVIORAL NEUROSCIENCE OF EATING
Leptin was abnormally high, rather than low, in almost all obese humans as well as in mice and rats that became obese on a high-fat diet. 4 knockout mice are hyperphagic and obese despite high circulating leptin. The endogenous agonist for the MC ... Fetch Doc

Obesity Researchers Identify Protein That Overcomes Leptin ...
Nearly all obese individuals are resistant to leptin, the hormone that signals the brain that our appetites are satisfied and we can stop eating. researchers created a group of knockout mice, which lacked the PTP1B protein. ... Read Article

Leptin (which regulates satiety and appetite), adiponectin (which heightens sensitivity of target cells to insulin) and resistin Hormone Stimulated Lipolysis Paradigm Slide 49 Slide 50 Perilipin Knockout mice Mechanism for Hormone-mediated lipolysis Gs/cAMP/PKA/HSL Pathway to ... Get Content Here

AMPK Integrates Nutrient And Hormonal Signals To Regulate ...
The anorexigenic hormones leptin and insulin also inhibit hypothalamic AMPK activity. Leptin’s effects on AMPK activity are localized to the arcuate and paraventricular (PVN) nuclei (Minokoshi et al. 2004) receptor knockout mice ... Read Full Source

Animal Models In Type 2 Diabetes Research: An Overview
Specific knockout mice have been engineered for the study of diabetes. leptin fails to elicit effect on food intake and body weight as there is defect in leptin receptor9. db/db mice have been commonly and extensively used for ... Document Viewer

Product Data D12450B - Home - Research Diets, Inc
To Leptin. J. Clin. Invest. 1997; 99:385-390. 2. Taheri S, et al. Distribution and quantification of immunoreactive orexin A in rat tissues. protein 3 gene knockout mice. J.Biol.Chem. 275: 16258-16266, 2000. 11. Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. ... Fetch Doc