TITTA SALOPURO Studies On Selected Human Obesity Candidate Genes
Genes encoding uncoupling proteins (UCP), -adrenergic receptors (BAR) and leptin receptor (LEPR) are involved in energy expenditure and lipid and glucose metabolism and long-term weight regulation, KO knockout LC leader cistron LD linkage disequilibrium. LDL low density lipoprotein LEP leptin ... Retrieve Document
Role Of leptin In The Regulation Of Lipid And Carbohydrate ...
Wzrost ekspresji genu ko - dującego leptynę niezależnie od insuliny wywołuje także glukoza oraz glukokortykosteroidy [33,39,56]. W inkubo - wanych skrawkach tkanki tłuszczowej człowieka działa- of a leptin receptor, OB-R. Cell, 1995; 83: 1263–1271 ... Doc Viewer
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Female with HH & missense mutation? in NH2 ASHG 2002 meeting 10/02 Conditional KO: not ovarian determinant, but instead important for 18:214-215. Clement et al. Nat 1998;392:398-401 Leptin Receptor Gene Mutation Obesity and HH Homozygous G to A in splice donor site (exon skipping ... Access Full Source
Anorexia Nervosa - Wikipedia, The Free Encyclopedia
Other studies of the 5HT 2A serotonin receptor (linked to regulation of feeding, mood, and anxiety), leptin and ghrelin; leptin is a hormone produced primarily by the fat cells in white adipose tissue of the body it has an inhibitory ... Read Article
Using Obese Mouse Models In Research: Special Considerations ...
The Y1-receptor KO mouse displays both obesity and reduced sensitivity to pentobarbital and avertin34–36, 32 REVIEW Volume 34, No. 2 Lab Animal February 2005. mutations in the OB (leptin) receptor.Science 271(5251), 994–996 (1996). 14. ... Visit Document
Murine Models To Investigate The Influence Of Diabetic ...
Gold thioglucose (GTG)-induced obesity-related type 2-diabetes in the apoE-KO mouse model 4.4. Leptin receptor-deficient (Leprdb/db) and leptin-deficient (Lepob/ob) mouse models 4.5. Defective insulin signaling and atherosclerosis: Insulin receptor and insulin receptor substrate 2-null mice 5. ... Read Document
Correlated with body mass and inversely related to insulin sensitivity Alters insulin signaling in the liver IL-6 KO mice develop mature-onset obesity and glucose Leptin Secreted by adipocytes Regulates food intake – satiety factor Leptin receptor is expressed in ... Content Retrieval
LeptinStimulatesBothJAK2-dependentand JAK2 ...
2 The abbreviations used are: LEPRb, long isoform of leptin receptor; JAK, januskinase;STAT,signaltransducersandactivatorsoftranscription;MEF, knock-out embryos (34) and infected with LEPRb lentiviruses to generate MEFKO-LEPRb cell lines, which stably express ... Access Content
The Contribution Of Animal Models To The Study Of Obesity
Knockout (KO) models with obese or lean phenotypes have been created since the characterization of the first obesity genes Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632–5 Levin BE, Dunn-Meynell AA (2000) Defence of body ... Fetch Full Source
Impaired Oxidative Metabolism And Inflammation Are ...
Resistance, and obesity. Indeed, we found that global knockout (KO) of the estrogen receptor (ER) leads to reduced oxygen uptake and caloric expenditure compared with wild-type (WT) mice. leptin 8-fold, P 0.007; PAI-1 71%, P 0.001; Table 1) in ER -KO animals following HFD. ... Read Full Source
Regulation Of T-Cell Inflammation By SOCS1 And SOCS3
KO-tg mice) can rescue neonatal death, lymphocytes (prob-Figure 3. Role of STATs and SOCS pro-teins in Th-cell differentiation. MG Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem. 2000;275:40649–40657. 12. Shi H, Tzameli I, Bjorbaek C, Flier JS. ... Access Doc
European Cells And Materials Vol. 7. Suppl. 1, 2004 (page 89 ...
Leptin receptor of the osteoblasts. Primary human osteoblast cell cultures (n=6) and osteoblasts from KO 25 ng/ml 50 ng/ml 100 ng/ml Leptin Con. OD Iliac crest HO * Figure 2:Increased proliferation (MTT) under exposure ... Fetch Document
Serum Leptin Levels In Septic Men Correlate Well With C ...
P. MARUNA1, 2, R. GÜRLICH3, R. FRA−KO3, M. HALUZ˝K2 1Institute of Pathological Physiology, 2Third Internal Department and 3First Department of Surgery, Leptin receptor gene knockout mice revealed an inherent deficit in lymphopoiesis. ... View Full Source
REVIEW AMPK As A Mediator Of Hormonal Signalling
AMPKa2-knockout (KO) and LKB1-KO mice were shown to have glucose intolerance and fasting-induced hyperglycaemia, Leptin- or leptin receptor-deficient rodents showed a decreased AMPK activity in the liver (Yu et al. 2004). In lean animals, leptin has been shown to ... Retrieve Here
Peroxisome Proliferator-activated receptor- : From ...
PPAR- knock-out (KO) mice. PPAR- / mice are completely devoid of adipose tissue and PPAR- protein- and peroxisome proliferator-activated receptor- on the leptin promoter. Journal of Biological Chemistry 272 5283–5290. Hotamisligil GS, ... View This Document
Research Article Related Commentary, Page 2753 Disruption Of ...
Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice P = NS for vehicle versus leptin+ in KO mice for both Ca2+ and insulin. n = 6 islets from 3 individual mice in each group. ... Access Full Source
Cmgm.stanford.edu - Computational Services And Bioinformatics ...
PYY analogs (small molecule mimics lacking) 9. Ghrelin (treatment of anorexia) SOCS-3 KO (combat insulin/leptin resistance) pro-Apoptotic peptides linked to peptides that respectively. In 1994, the leptin gene was positionally cloned from the ob mouse; the leptin receptor was subsequently ... View Document
Endocannabinoids May Mediate The Ability Of (n-3) Fatty Acids ...
An inactivating mutation in the leptin receptor (25), inducing hyperphagia and resulting in visceral obesity and ectopic lipid activated endocannabionid system by blocking the receptor, dietary (n-3) LCPUFA, and KO in particular, may reduce the ... Content Retrieval
Adrenocorticotropic Hormone - Wikipedia, The Free Encyclopedia
Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A. Adipose tissue: leptin ... Read Article
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Evidence that MC4R is an “obesity gene” Biological candidate Invalidation in mouse models leads to obesity (KO) and its subsequent interaction with the leptin receptor (LEPR) located on the surface of neurons of the arcuate nucleus region of the hypothalamus. ... Document Viewer
Behavioral/Systems/Cognitive ... - The Journal Of Neuroscience
Knock-out (KO) mice was shown to also result in the develop-ment of obesity (Majdic et al., 2002). 3 -untranslated region of the leptin receptor (LepRb)-specific exon of Lepr(Leshanetal.,2006).Hence,inLeprcremice,thecrecodingsequence ... Retrieve Content
83. Novel Mechanisms In The Pathogenesis Of Asthma
A novel receptor antagonist, c-027, inhibits airway contraction in human and leptin and adiponectin are unlikely to mediate the previously observed association (KO) and a reversal approach administering recombinant mouse OPN ... Doc Retrieval
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